Assay Detail
Functional
CHEMBL1000149
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Cytotoxicity against human NCI-H838 cells after 72 hrs by MTT assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | NCI-H838 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Targeting the delivery of glycan-based paclitaxel prodrugs to cancer cells via glucose transporters.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.88 | 7.58 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 7.58 |
| CHEMBL508383 | — | — | 1 | 7.09 |
| CHEMBL445422 | — | — | 1 | 6.74 |
| CHEMBL499652 | — | — | 1 | 6.57 |
| CHEMBL509765 | — | — | 1 | 6.43 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL428647 | PACLITAXEL | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL508383 | — | IC50 | = | 82.0 | nM | 7.09 |
| CHEMBL445422 | — | IC50 | = | 181.0 | nM | 6.74 |
| CHEMBL499652 | — | IC50 | = | 267.0 | nM | 6.57 |
| CHEMBL509765 | — | IC50 | = | 374.0 | nM | 6.43 |