Assay Detail
Binding
CHEMBL1000392
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human recombinant GAR transformylase
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Trifunctional purine biosynthetic protein adenosine-3 (CHEMBL3972) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Asymmetric synthesis of inhibitors of glycinamide ribonucleotide transformylase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 11 | 6.53 | 7.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL451819 | — | — | 1 | 7.85 |
| CHEMBL451818 | — | — | 1 | 7.82 |
| CHEMBL34412 | LOMETREXOL | 2.0 | 1 | 7.22 |
| CHEMBL452322 | — | — | 1 | 6.75 |
| CHEMBL453090 | — | — | 1 | 6.68 |
| CHEMBL452324 | — | — | 1 | 6.07 |
| CHEMBL452837 | — | — | 1 | 5.96 |
| CHEMBL453089 | — | — | 1 | 5.96 |
| CHEMBL508910 | — | — | 1 | 5.92 |
| CHEMBL453348 | — | — | 1 | 5.85 |
| CHEMBL13705 | DIDEAZAACYCLOTETRAHYDROFOLIC ACID | — | 1 | 5.77 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL451819 | — | Ki | = | 14.0 | nM | 7.85 |
| CHEMBL451818 | — | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL34412 | LOMETREXOL | Ki | = | 60.0 | nM | 7.22 |
| CHEMBL452322 | — | Ki | = | 180.0 | nM | 6.75 |
| CHEMBL453090 | — | Ki | = | 210.0 | nM | 6.68 |
| CHEMBL452324 | — | Ki | = | 850.0 | nM | 6.07 |
| CHEMBL452837 | — | Ki | = | 1100.0 | nM | 5.96 |
| CHEMBL453089 | — | Ki | = | 1100.0 | nM | 5.96 |
| CHEMBL508910 | — | Ki | = | 1200.0 | nM | 5.92 |
| CHEMBL453348 | — | Ki | = | 1400.0 | nM | 5.85 |
| CHEMBL13705 | DIDEAZAACYCLOTETRAHYDROFOLIC ACID | Ki | = | 1700.0 | nM | 5.77 |