Assay Detail
Binding
CHEMBL1000393
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Inhibition of human recombinant AICAR transformylase
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Bifunctional purine biosynthesis protein ATIC (CHEMBL2518) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Asymmetric synthesis of inhibitors of glycinamide ribonucleotide transformylase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 10 | 4.70 | 4.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL13705 | DIDEAZAACYCLOTETRAHYDROFOLIC ACID | — | 1 | 4.70 |
| CHEMBL452837 | — | — | 1 | 4.70 |
| CHEMBL453090 | — | — | 1 | - |
| CHEMBL34412 | LOMETREXOL | 2.0 | 1 | - |
| CHEMBL451818 | — | — | 1 | - |
| CHEMBL508910 | — | — | 1 | - |
| CHEMBL452324 | — | — | 1 | - |
| CHEMBL453348 | — | — | 1 | - |
| CHEMBL453089 | — | — | 1 | - |
| CHEMBL452322 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL13705 | DIDEAZAACYCLOTETRAHYDROFOLIC ACID | Ki | = | 20000.0 | nM | 4.70 |
| CHEMBL452837 | — | Ki | = | 20000.0 | nM | 4.70 |
| CHEMBL453090 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL34412 | LOMETREXOL | Ki | > | 100000.0 | nM | - |
| CHEMBL451818 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL508910 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL452324 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL453348 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL453089 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL452322 | — | Ki | > | 100000.0 | nM | - |