Assay Detail

CHEMBL1000424

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding

Inhibition of PDE4 in dog trachea

ChEMBL ↗

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Target

Unchecked (CHEMBL612545) ↗

Open DB target context

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Unchecked (CHEMBL612545) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target Unchecked

CHEMBL612545

Anchored from Assay target.

Protein identity Unchecked

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Organism	Canis lupus familiaris
Tissue	Trachea
Confidence	0 — Uncurated / Unknown
Curated By	Autocuration

Target

Unchecked (CHEMBL612545) ↗

Type

UNCHECKED

Publication

Recent advances on phosphodiesterase 4 inhibitors for the treatment of asthma and chronic obstructive pulmonary disease.

Kodimuthali A, Jabaris SS, Pal M.
J Med Chem (2008) 51 : 5471 -5489
PubMed 18686943 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	1	6.80	6.80

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL313842	ZARDAVERINE	2.0	1	6.80

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL313842	ZARDAVERINE	IC50	=	158.49	nM	6.80