Assay Detail
Binding
CHEMBL1000461
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Displacement of [125I]alpha-bungarotoxin from alpha7 nAChR in rat cortical membrane
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Neuronal acetylcholine receptor subunit alpha-7 (CHEMBL4980) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Epiboxidine and novel-related analogues: a convenient synthetic approach and estimation of their affinity at neuronal nicotinic acetylcholine receptor subtypes.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 6.60 | 8.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL503604 | EXO-EPIBOXIDINE | — | 1 | 8.22 |
| CHEMBL504313 | ENDO-EPIBOXIDINE | — | 1 | 6.64 |
| CHEMBL525968 | — | — | 1 | 6.41 |
| CHEMBL274525 | ABT-418 | — | 1 | 5.92 |
| CHEMBL449716 | — | — | 1 | 5.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL503604 | EXO-EPIBOXIDINE | Ki | = | 6.0 | nM | 8.22 |
| CHEMBL504313 | ENDO-EPIBOXIDINE | Ki | = | 230.0 | nM | 6.64 |
| CHEMBL525968 | — | Ki | = | 394.0 | nM | 6.41 |
| CHEMBL274525 | ABT-418 | Ki | = | 1200.0 | nM | 5.92 |
| CHEMBL449716 | — | Ki | = | 1600.0 | nM | 5.80 |