Assay Detail
Binding
CHEMBL1000653
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Inhibition of HRV-16 protease 3C expressed in Escherichia coli BL21(DE3) by FRET assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | rhinovirus A16 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Structure-activity relationships of heteroaromatic esters as human rhinovirus 3C protease inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.53 | 7.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL222234 | — | — | 1 | 7.10 |
| CHEMBL506171 | — | — | 1 | 6.70 |
| CHEMBL496709 | — | — | 1 | 6.54 |
| CHEMBL496214 | — | — | 1 | 6.16 |
| CHEMBL466351 | — | — | 1 | 6.15 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL222234 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL506171 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL496709 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL496214 | — | IC50 | = | 690.0 | nM | 6.16 |
| CHEMBL466351 | — | IC50 | = | 710.0 | nM | 6.15 |