Assay Detail
Functional
CHEMBL1000705
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Cytotoxicity against human RPMI8226 cells by MTT method
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | RPMI-8226 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Cytotoxicity and TOP1-targeting activity of 8- and 9-amino derivatives of 5-butyl- and 5-(2-N,N-dimethylamino)ethyl-5H-dibenzo[c,h][1,6]naphthyridin-6-ones.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 6.81 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL309355 | — | — | 1 | 8.70 |
| CHEMBL72772 | — | — | 1 | 8.30 |
| CHEMBL65 | CAMPTOTHECIN | -1.0 | 1 | 8.22 |
| CHEMBL84 | TOPOTECAN | 4.0 | 1 | 7.68 |
| CHEMBL309352 | — | — | 1 | 7.48 |
| CHEMBL528538 | — | — | 1 | 7.46 |
| CHEMBL72223 | — | — | 1 | 7.05 |
| CHEMBL487129 | — | — | 1 | 6.92 |
| CHEMBL488371 | — | — | 1 | 6.92 |
| CHEMBL487130 | — | — | 1 | 6.52 |
| CHEMBL488370 | — | — | 1 | 6.48 |
| CHEMBL483808 | — | — | 1 | 6.32 |
| CHEMBL486928 | — | — | 1 | 6.07 |
| CHEMBL306476 | — | — | 1 | 5.90 |
| CHEMBL486929 | — | — | 1 | 5.80 |
| CHEMBL485170 | — | — | 1 | 5.75 |
| CHEMBL73950 | — | — | 1 | 5.62 |
| CHEMBL484993 | — | — | 1 | 5.46 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL309355 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL72772 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL65 | CAMPTOTHECIN | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL84 | TOPOTECAN | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL309352 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL528538 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL72223 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL487129 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL488371 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL487130 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL488370 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL483808 | — | IC50 | = | 480.0 | nM | 6.32 |
| CHEMBL486928 | — | IC50 | = | 850.0 | nM | 6.07 |
| CHEMBL306476 | — | IC50 | = | 1250.0 | nM | 5.90 |
| CHEMBL486929 | — | IC50 | = | 1570.0 | nM | 5.80 |
| CHEMBL485170 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL73950 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL484993 | — | IC50 | = | 3500.0 | nM | 5.46 |