Assay Detail
Functional
CHEMBL1001107
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against human MDA-MB-231 cells after 48 hrs by alamar blue assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MDA-MB-231 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis and biological evaluation of novel stilbene-based antitumor agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 7.10 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL67 | COMBRETASTATIN A4 | -1.0 | 1 | 8.40 |
| CHEMBL90555 | VINCRISTINE | 4.0 | 1 | 7.82 |
| CHEMBL107 | COLCHICINE | 4.0 | 1 | 7.70 |
| CHEMBL490294 | — | — | 1 | 7.52 |
| CHEMBL524493 | — | — | 1 | 7.10 |
| CHEMBL502199 | — | — | 1 | 7.10 |
| CHEMBL490295 | — | — | 1 | 6.60 |
| CHEMBL491277 | — | — | 1 | 6.60 |
| CHEMBL521616 | — | — | 1 | 6.10 |
| CHEMBL454401 | — | — | 1 | 6.10 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL67 | COMBRETASTATIN A4 | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL90555 | VINCRISTINE | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL107 | COLCHICINE | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL490294 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL524493 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL502199 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL490295 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL491277 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL521616 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL454401 | — | IC50 | = | 800.0 | nM | 6.10 |