Assay Detail
Binding
CHEMBL1001387
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]nisoxetine from human NET expressed in HEK293 cells
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Sodium-dependent noradrenaline transporter (CHEMBL222) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
3-(4-(6-Fluoroalkoxy-3,4-dihydroisoquinoline-2(1H)-yl)cyclohexyl)-1H-indole-5-carbonitriles for SERT imaging: chemical synthesis, evaluation in vitro and radiofluorination.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 6.45 | 7.01 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL293583 | — | — | 1 | 7.01 |
| CHEMBL477587 | — | — | 1 | 6.99 |
| CHEMBL55505 | — | — | 1 | 6.74 |
| CHEMBL449277 | — | — | 1 | 6.11 |
| CHEMBL294481 | — | — | 1 | 5.99 |
| CHEMBL54465 | — | — | 1 | 5.84 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL293583 | — | Ki | = | 96.7 | nM | 7.01 |
| CHEMBL477587 | — | Ki | = | 102.0 | nM | 6.99 |
| CHEMBL55505 | — | Ki | = | 184.0 | nM | 6.74 |
| CHEMBL449277 | — | Ki | = | 772.0 | nM | 6.11 |
| CHEMBL294481 | — | Ki | = | 1020.0 | nM | 5.99 |
| CHEMBL54465 | — | Ki | = | 1430.0 | nM | 5.84 |