Assay Detail
Functional
CHEMBL1001567
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Antagonist activity at human recombinant kappa opioid receptor expressed in CHO cells coexpressing alphaqi5 assessed as inhibition of dynorphin A-induced intracellular calcium mobilization
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Further studies at neuropeptide s position 5: discovery of novel neuropeptide S receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 2 | 8.42 | 8.63 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1627325 | — | — | 1 | 8.63 |
| CHEMBL411557 | DYNORPHIN A (1-17) | — | 1 | 8.20 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1627325 | — | EC50 | = | 2.344 | nM | 8.63 |
| CHEMBL411557 | DYNORPHIN A (1-17) | EC50 | = | 6.31 | nM | 8.20 |