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Assay Detail

CHEMBL1001817

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antiplasmodial activity against chloroquine and pyrimethamine-resistant Plasmodium falciparum K1
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Plasmodium falciparum
Confidence 1 — Organism
Curated By Autocuration

Target

Plasmodium falciparum (CHEMBL364)
Type ORGANISM
Organism Plasmodium falciparum

Publication

Synthesis and in vitro antiprotozoal activities of water-soluble, inexpensive 3,7-bis(dialkylamino)phenoxazin-5-ium derivatives.
Ge JF, Arai C, Kaiser M, Wittlin S, Brun R, Ihara M.
J Med Chem (2008) 51 : 3654 -3658
PubMed 18476684 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 21 8.12 8.70

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL484303 1 8.70
CHEMBL520624 1 8.70
CHEMBL389921 1 8.52
CHEMBL483707 1 8.52
CHEMBL482921 1 8.52
CHEMBL482920 1 8.52
CHEMBL485117 1 8.52
CHEMBL482930 1 8.40
CHEMBL482494 1 8.30
CHEMBL482892 1 8.30
CHEMBL482495 1 8.22
CHEMBL520012 1 8.22
CHEMBL485116 1 8.22
CHEMBL482719 1 8.15
CHEMBL482925 1 8.15
CHEMBL482694 1 8.10
CHEMBL482924 1 8.10
CHEMBL520124 1 7.64
CHEMBL482493 1 7.54
CHEMBL76 CHLOROQUINE 4.0 1 6.83
CHEMBL484915 1 6.37

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL484303 IC50 = 2.0 nM 8.70
CHEMBL520624 IC50 = 2.0 nM 8.70
CHEMBL389921 IC50 = 3.0 nM 8.52
CHEMBL483707 IC50 = 3.0 nM 8.52
CHEMBL482921 IC50 = 3.0 nM 8.52
CHEMBL482920 IC50 = 3.0 nM 8.52
CHEMBL485117 IC50 = 3.0 nM 8.52
CHEMBL482930 IC50 = 4.0 nM 8.40
CHEMBL482494 IC50 = 5.0 nM 8.30
CHEMBL482892 IC50 = 5.0 nM 8.30
CHEMBL482495 IC50 = 6.0 nM 8.22
CHEMBL520012 IC50 = 6.0 nM 8.22
CHEMBL485116 IC50 = 6.0 nM 8.22
CHEMBL482719 IC50 = 7.0 nM 8.15
CHEMBL482925 IC50 = 7.0 nM 8.15
CHEMBL482694 IC50 = 8.0 nM 8.10
CHEMBL482924 IC50 = 8.0 nM 8.10
CHEMBL520124 IC50 = 23.0 nM 7.64
CHEMBL482493 IC50 = 29.0 nM 7.54
CHEMBL76 CHLOROQUINE IC50 = 148.0 nM 6.83
CHEMBL484915 IC50 = 431.0 nM 6.37