Assay Detail
Functional
CHEMBL1002006
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Antimalarial activity against Plasmodium falciparum 3D7 infected human erythrocytes after 24 hrs by [3H]hypoxanthine uptake
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Piperidine dispiro-1,2,4-trioxane analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 7.31 | 8.90 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL566534 | ARTEMETHER | 4.0 | 1 | 8.90 |
| CHEMBL406928 | — | — | 1 | 8.21 |
| CHEMBL269671 | ARTEMISININ | 3.0 | 1 | 8.02 |
| CHEMBL410640 | — | — | 1 | 7.97 |
| CHEMBL498554 | — | — | 1 | 6.92 |
| CHEMBL523408 | — | — | 1 | 6.76 |
| CHEMBL495957 | — | — | 1 | 6.75 |
| CHEMBL496161 | — | — | 1 | 6.74 |
| CHEMBL498761 | — | — | 1 | 6.70 |
| CHEMBL261500 | — | — | 1 | 6.15 |
| CHEMBL405890 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL566534 | ARTEMETHER | IC50 | = | 1.26 | nM | 8.90 |
| CHEMBL406928 | — | IC50 | = | 6.22 | nM | 8.21 |
| CHEMBL269671 | ARTEMISININ | IC50 | = | 9.54 | nM | 8.02 |
| CHEMBL410640 | — | IC50 | = | 10.72 | nM | 7.97 |
| CHEMBL498554 | — | IC50 | = | 121.33 | nM | 6.92 |
| CHEMBL523408 | — | IC50 | = | 174.23 | nM | 6.76 |
| CHEMBL495957 | — | IC50 | = | 179.62 | nM | 6.75 |
| CHEMBL496161 | — | IC50 | = | 183.45 | nM | 6.74 |
| CHEMBL498761 | — | IC50 | = | 197.86 | nM | 6.70 |
| CHEMBL261500 | — | IC50 | = | 710.23 | nM | 6.15 |
| CHEMBL405890 | — | IC50 | > | 1000.0 | nM | - |