Assay Detail
Binding
CHEMBL1002021
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human CDK2 by HTRF assay
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and evaluation of pyrazolo[1,5-b]pyridazines as selective cyclin dependent kinase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 7.59 | 9.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL526110 | — | — | 1 | 9.52 |
| CHEMBL359794 | — | — | 1 | 8.70 |
| CHEMBL495696 | GW778894X | — | 1 | 8.70 |
| CHEMBL188938 | — | — | 1 | 8.52 |
| CHEMBL497564 | — | — | 1 | 8.52 |
| CHEMBL468963 | GW779439X | — | 1 | 8.40 |
| CHEMBL359554 | — | — | 1 | 8.10 |
| CHEMBL523735 | — | — | 1 | 7.80 |
| CHEMBL359963 | GW805758X | — | 1 | 7.40 |
| CHEMBL524059 | — | — | 1 | 7.40 |
| CHEMBL495751 | — | — | 1 | 7.40 |
| CHEMBL513354 | — | — | 1 | 7.30 |
| CHEMBL495545 | — | — | 1 | 7.00 |
| CHEMBL525194 | — | — | 1 | 6.92 |
| CHEMBL496162 | — | — | 1 | 6.64 |
| CHEMBL521871 | — | — | 1 | 6.35 |
| CHEMBL513330 | GW781673X | — | 1 | 6.00 |
| CHEMBL446024 | GW683003X | — | 1 | 6.00 |
| CHEMBL522718 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL526110 | — | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL359794 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL495696 | GW778894X | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL188938 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL497564 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL468963 | GW779439X | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL359554 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL523735 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL359963 | GW805758X | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL524059 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL495751 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL513354 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL495545 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL525194 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL496162 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL521871 | — | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL513330 | GW781673X | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL446024 | GW683003X | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL522718 | — | IC50 | > | 25000.0 | nM | - |