Assay Detail
Functional
CHEMBL1002173
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Agonist activity against human GPR109a assessed as forskolin-induced cAMP accumulation
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
3-(1H-tetrazol-5-yl)-1,4,5,6-tetrahydro-cyclopentapyrazole (MK-0354): a partial agonist of the nicotinic acid receptor, G-protein coupled receptor 109a, with antilipolytic but no vasodilatory activity in mice.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 3 | 5.64 | 6.07 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL128604 | — | — | 1 | 6.07 |
| CHEMBL456145 | — | — | 1 | 5.78 |
| CHEMBL394688 | — | — | 1 | 5.08 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL128604 | — | EC50 | = | 860.0 | nM | 6.07 |
| CHEMBL456145 | — | EC50 | = | 1650.0 | nM | 5.78 |
| CHEMBL394688 | — | EC50 | = | 8300.0 | nM | 5.08 |