Assay Detail
Binding
CHEMBL1002226
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Inhibition of human CYP11B2 expressed in hamster V79 MZh cells
30
Total Activities
30
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | V79 MZh |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Overcoming undesirable CYP1A2 inhibition of pyridylnaphthalene-type aldosterone synthase inhibitors: influence of heteroaryl derivatization on potency and selectivity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 30 | 8.47 | 9.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL500392 | — | — | 1 | 9.70 |
| CHEMBL500421 | — | — | 1 | 9.70 |
| CHEMBL500395 | — | — | 1 | 9.30 |
| CHEMBL499044 | — | — | 1 | 9.30 |
| CHEMBL500394 | — | — | 1 | 9.22 |
| CHEMBL500665 | — | — | 1 | 9.22 |
| CHEMBL500146 | — | — | 1 | 9.10 |
| CHEMBL500664 | — | — | 1 | 9.10 |
| CHEMBL9298 | FADROZOLE | 2.0 | 1 | 9.00 |
| CHEMBL500145 | — | — | 1 | 8.92 |
| CHEMBL502824 | — | — | 1 | 8.68 |
| CHEMBL206351 | — | — | 1 | 8.68 |
| CHEMBL500676 | — | — | 1 | 8.66 |
| CHEMBL196796 | — | — | 1 | 8.54 |
| CHEMBL525785 | — | — | 1 | 8.51 |
| CHEMBL502266 | — | — | 1 | 8.48 |
| CHEMBL502818 | — | — | 1 | 8.42 |
| CHEMBL447591 | — | — | 1 | 8.38 |
| CHEMBL500663 | — | — | 1 | 8.35 |
| CHEMBL500393 | — | — | 1 | 8.32 |
| CHEMBL445259 | — | — | 1 | 8.29 |
| CHEMBL362968 | — | — | 1 | 8.21 |
| CHEMBL526339 | — | — | 1 | 8.16 |
| CHEMBL499871 | — | — | 1 | 8.15 |
| CHEMBL448064 | — | — | 1 | 8.04 |
| CHEMBL453169 | — | — | 1 | 7.89 |
| CHEMBL449894 | — | — | 1 | 7.66 |
| CHEMBL500636 | — | — | 1 | 7.03 |
| CHEMBL502823 | — | — | 1 | 7.03 |
| CHEMBL501740 | — | — | 1 | 5.92 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL500392 | — | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL500421 | — | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL500395 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL499044 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL500394 | — | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL500665 | — | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL500146 | — | IC50 | = | 0.8 | nM | 9.10 |
| CHEMBL500664 | — | IC50 | = | 0.8 | nM | 9.10 |
| CHEMBL9298 | FADROZOLE | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL500145 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL502824 | — | IC50 | = | 2.1 | nM | 8.68 |
| CHEMBL206351 | — | IC50 | = | 2.1 | nM | 8.68 |
| CHEMBL500676 | — | IC50 | = | 2.2 | nM | 8.66 |
| CHEMBL196796 | — | IC50 | = | 2.9 | nM | 8.54 |
| CHEMBL525785 | — | IC50 | = | 3.1 | nM | 8.51 |
| CHEMBL502266 | — | IC50 | = | 3.3 | nM | 8.48 |
| CHEMBL502818 | — | IC50 | = | 3.8 | nM | 8.42 |
| CHEMBL447591 | — | IC50 | = | 4.2 | nM | 8.38 |
| CHEMBL500663 | — | IC50 | = | 4.5 | nM | 8.35 |
| CHEMBL500393 | — | IC50 | = | 4.8 | nM | 8.32 |
| CHEMBL445259 | — | IC50 | = | 5.1 | nM | 8.29 |
| CHEMBL362968 | — | IC50 | = | 6.2 | nM | 8.21 |
| CHEMBL526339 | — | IC50 | = | 6.9 | nM | 8.16 |
| CHEMBL499871 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL448064 | — | IC50 | = | 9.1 | nM | 8.04 |
| CHEMBL453169 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL449894 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL500636 | — | IC50 | = | 94.0 | nM | 7.03 |
| CHEMBL502823 | — | IC50 | = | 94.0 | nM | 7.03 |
| CHEMBL501740 | — | IC50 | = | 1216.0 | nM | 5.92 |