Assay Detail
Functional
CHEMBL1002436
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonist activity at histamine H1 receptor in guinea pig ileum assessed as histamine-induced contractions
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cavia porcellus |
| Tissue | Ileum |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Non-imidazole histamine H3 ligands, part IV: SAR of 1-[2-thiazol-5-yl-(2-aminoethyl)]-4-n-propylpiperazine derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 5 | 8.96 | 8.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL511 | PYRILAMINE | 4.0 | 1 | 8.96 |
| CHEMBL475323 | — | — | 1 | - |
| CHEMBL473093 | — | — | 1 | - |
| CHEMBL472690 | — | — | 1 | - |
| CHEMBL514976 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL511 | PYRILAMINE | Kd | = | 1.096 | nM | 8.96 |
| CHEMBL475323 | — | Kd | > | 100000.0 | nM | - |
| CHEMBL473093 | — | Kd | > | 100000.0 | nM | - |
| CHEMBL472690 | — | Kd | > | 100000.0 | nM | - |
| CHEMBL514976 | — | Kd | > | 100000.0 | nM | - |