Assay Detail
Functional
CHEMBL1002568
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Cytotoxicity against human MCF7 cells after 96 hrs by MTT assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MCF7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Phelligridins C-F: cytotoxic pyrano[4,3-c][2]benzopyran-1,6-dione and furo[3,2-c]pyran-4-one derivatives from the fungus Phellinus igniarius.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 7.31 | 8.74 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL84 | TOPOTECAN | 4.0 | 1 | 8.74 |
| CHEMBL452722 | HISPOLON | — | 1 | 7.60 |
| CHEMBL218423 | PHELLIGRIDIN D | — | 1 | 7.43 |
| CHEMBL236399 | PHELLIGRIDIN E | — | 1 | 7.16 |
| CHEMBL520568 | PHELLIGRIDIN C | — | 1 | 7.14 |
| CHEMBL488197 | PHELLIGRIDIN F | — | 1 | 7.07 |
| CHEMBL446850 | PHELLIGRIDIN A | — | 1 | 6.96 |
| CHEMBL75390 | — | — | 1 | 6.85 |
| CHEMBL470046 | PHELLIGRIDIN B | — | 1 | 6.84 |
| CHEMBL487596 | INOSCAVIN A | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL84 | TOPOTECAN | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL452722 | HISPOLON | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL218423 | PHELLIGRIDIN D | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL236399 | PHELLIGRIDIN E | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL520568 | PHELLIGRIDIN C | IC50 | = | 72.0 | nM | 7.14 |
| CHEMBL488197 | PHELLIGRIDIN F | IC50 | = | 85.0 | nM | 7.07 |
| CHEMBL446850 | PHELLIGRIDIN A | IC50 | = | 109.0 | nM | 6.96 |
| CHEMBL75390 | — | IC50 | = | 141.0 | nM | 6.85 |
| CHEMBL470046 | PHELLIGRIDIN B | IC50 | = | 143.0 | nM | 6.84 |
| CHEMBL487596 | INOSCAVIN A | IC50 | > | 108.0 | nM | - |