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Assay Detail

CHEMBL1002586

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Functional
Cytotoxicity against human KB cells
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type KB
Confidence 1 — Organism
Curated By Autocuration

Target

KB (CHEMBL398)
Type CELL-LINE
Organism Homo sapiens

Publication

Cytotoxic arylnaphthalene lignans from a Vietnamese acanthaceae, Justicia patentiflora.
Susplugas S, Hung NV, Bignon J, Thoison O, Kruczynski A, Sévenet T, Guéritte F.
J Nat Prod (2005) 68 : 734 -738
PubMed 15921419 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 10 7.56 8.70

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3545252 DOCETAXEL 4.0 1 8.70
CHEMBL458904 PATENTIFLORIN A 1 8.40
CHEMBL458905 PATENTIFLORIN B 1 8.22
CHEMBL505932 1 7.85
CHEMBL444750 1 7.70
CHEMBL454803 4'-O-ACETYLPATENTIFLORIN B 1 7.62
CHEMBL449447 1 6.75
CHEMBL518690 JUSTICINOL 1 6.52
CHEMBL452903 4'-O-ACETYLMANANTHOSIDE B 1 6.30
CHEMBL463731 JUSTIFLORINOL 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3545252 DOCETAXEL IC50 = 2.0 nM 8.70
CHEMBL458904 PATENTIFLORIN A IC50 = 4.0 nM 8.40
CHEMBL458905 PATENTIFLORIN B IC50 = 6.0 nM 8.22
CHEMBL505932 IC50 = 14.0 nM 7.85
CHEMBL444750 IC50 = 20.0 nM 7.70
CHEMBL454803 4'-O-ACETYLPATENTIFLORIN B IC50 = 24.0 nM 7.62
CHEMBL449447 IC50 = 180.0 nM 6.75
CHEMBL518690 JUSTICINOL IC50 = 300.0 nM 6.52
CHEMBL452903 4'-O-ACETYLMANANTHOSIDE B IC50 = 500.0 nM 6.30
CHEMBL463731 JUSTIFLORINOL IC50 > 10000.0 nM -