Assay Detail
Functional
CHEMBL1002588
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Cytotoxicity against doxorubicin-resistant human MCF7 cells
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MCF7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Cytotoxic arylnaphthalene lignans from a Vietnamese acanthaceae, Justicia patentiflora.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.11 | 7.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL458904 | PATENTIFLORIN A | — | 1 | 7.40 |
| CHEMBL505932 | — | — | 1 | 7.19 |
| CHEMBL454803 | 4'-O-ACETYLPATENTIFLORIN B | — | 1 | 7.00 |
| CHEMBL452903 | 4'-O-ACETYLMANANTHOSIDE B | — | 1 | 5.66 |
| CHEMBL449447 | — | — | 1 | 5.10 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 4.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL458904 | PATENTIFLORIN A | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL505932 | — | IC50 | = | 65.0 | nM | 7.19 |
| CHEMBL454803 | 4'-O-ACETYLPATENTIFLORIN B | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL452903 | 4'-O-ACETYLMANANTHOSIDE B | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL449447 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 50000.0 | nM | 4.30 |