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Assay Detail

CHEMBL1002674

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antiviral activity against HSV1 infected in monkey CV-1 cells assessed as inhibition of plaque formation
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Human alphaherpesvirus 1
Cell Type CV-1
Confidence 1 — Organism
Curated By Autocuration

Target

Human alphaherpesvirus 1 (CHEMBL377)
Type ORGANISM
Organism Human alphaherpesvirus 1

Publication

Antiviral activity of lignans.
Charlton JL.
J Nat Prod (1998) 61 : 1447 -1451
PubMed 9834179 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 11 6.63 7.64

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL483004 1 7.64
CHEMBL63970 DESOXYPODOPHYLLOTOXIN 1 7.60
CHEMBL61 PODOFILOX 4.0 1 7.30
CHEMBL28941 1 7.00
CHEMBL485470 1 6.60
CHEMBL483410 EPIPODOPHYLLOTOXIN ACETATE 1 6.36
CHEMBL471390 1 6.34
CHEMBL485672 1 6.34
CHEMBL511650 1 6.05
CHEMBL468247 1 6.05
CHEMBL519603 DEOXYPICROPODOPHYLLIN 1 5.70

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL483004 IC50 = 23.0 nM 7.64
CHEMBL63970 DESOXYPODOPHYLLOTOXIN IC50 = 25.0 nM 7.60
CHEMBL61 PODOFILOX IC50 = 50.0 nM 7.30
CHEMBL28941 IC50 = 100.0 nM 7.00
CHEMBL485470 IC50 = 250.0 nM 6.60
CHEMBL483410 EPIPODOPHYLLOTOXIN ACETATE IC50 = 440.0 nM 6.36
CHEMBL471390 IC50 = 460.0 nM 6.34
CHEMBL485672 IC50 = 460.0 nM 6.34
CHEMBL511650 IC50 = 900.0 nM 6.05
CHEMBL468247 IC50 = 900.0 nM 6.05
CHEMBL519603 DEOXYPICROPODOPHYLLIN IC50 = 2000.0 nM 5.70