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Assay Detail

CHEMBL1002675

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antiviral activity against VSV infected in BHK cells assessed as inhibition of plaque formation
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Vesicular stomatitis virus
Cell Type BHK
Confidence 1 — Organism
Curated By Autocuration

Target

Vesicular stomatitis virus (CHEMBL613739)
Type ORGANISM
Organism Vesicular stomatitis virus

Publication

Antiviral activity of lignans.
Charlton JL.
J Nat Prod (1998) 61 : 1447 -1451
PubMed 9834179 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 11 6.43 7.64

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL483004 1 7.64
CHEMBL61 PODOFILOX 4.0 1 7.00
CHEMBL483410 EPIPODOPHYLLOTOXIN ACETATE 1 6.66
CHEMBL28941 1 6.60
CHEMBL485470 1 6.60
CHEMBL485672 1 6.34
CHEMBL511650 1 6.05
CHEMBL471390 1 6.03
CHEMBL519603 DEOXYPICROPODOPHYLLIN 1 5.70
CHEMBL468247 1 5.64
CHEMBL63970 DESOXYPODOPHYLLOTOXIN 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL483004 IC50 = 23.0 nM 7.64
CHEMBL61 PODOFILOX IC50 = 100.0 nM 7.00
CHEMBL483410 EPIPODOPHYLLOTOXIN ACETATE IC50 = 220.0 nM 6.66
CHEMBL28941 IC50 = 250.0 nM 6.60
CHEMBL485470 IC50 = 250.0 nM 6.60
CHEMBL485672 IC50 = 460.0 nM 6.34
CHEMBL511650 IC50 = 900.0 nM 6.05
CHEMBL471390 IC50 = 930.0 nM 6.03
CHEMBL519603 DEOXYPICROPODOPHYLLIN IC50 = 2000.0 nM 5.70
CHEMBL468247 IC50 = 2300.0 nM 5.64
CHEMBL63970 DESOXYPODOPHYLLOTOXIN IC50 < 25.0 nM -