Assay Detail
Functional
CHEMBL1002733
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against paclitaxel-resistant human 1A9 cells after 3 days by SRB assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | 1A9 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Antitumor agents. 233. Lantalucratins A-F, new cytotoxic naphthoquinones from Lantana involucrata.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.53 | 5.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL448558 | LANTALUCRATIN B | — | 1 | 5.68 |
| CHEMBL510369 | — | — | 1 | 5.64 |
| CHEMBL487397 | LANTALUCRATIN E | — | 1 | 5.60 |
| CHEMBL221630 | DEHYDROISO-ALPHA-LAPACHONE | — | 1 | 5.55 |
| CHEMBL470256 | LANTALUCRATIN C | — | 1 | 5.19 |
| CHEMBL447062 | LANTALUCRATIN A | — | 1 | - |
| CHEMBL15192 | LAPACHONE | 2.0 | 1 | - |
| CHEMBL451534 | LANTALUCRATIN D | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL448558 | LANTALUCRATIN B | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL510369 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL487397 | LANTALUCRATIN E | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL221630 | DEHYDROISO-ALPHA-LAPACHONE | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL470256 | LANTALUCRATIN C | IC50 | = | 6500.0 | nM | 5.19 |
| CHEMBL447062 | LANTALUCRATIN A | IC50 | > | 5000.0 | nM | - |
| CHEMBL15192 | LAPACHONE | IC50 | > | 800.0 | nM | - |
| CHEMBL451534 | LANTALUCRATIN D | IC50 | > | 10000.0 | nM | - |