Assay Detail
Functional
CHEMBL1002736
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Cytotoxicity against human MCF7 cells after 3 days by SRB assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MCF7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Antitumor agents. 233. Lantalucratins A-F, new cytotoxic naphthoquinones from Lantana involucrata.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 5.76 | 6.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL15192 | LAPACHONE | 2.0 | 1 | 6.10 |
| CHEMBL448558 | LANTALUCRATIN B | — | 1 | 6.00 |
| CHEMBL221630 | DEHYDROISO-ALPHA-LAPACHONE | — | 1 | 5.92 |
| CHEMBL510369 | — | — | 1 | 5.92 |
| CHEMBL447062 | LANTALUCRATIN A | — | 1 | 5.80 |
| CHEMBL470256 | LANTALUCRATIN C | — | 1 | 5.31 |
| CHEMBL487397 | LANTALUCRATIN E | — | 1 | 5.26 |
| CHEMBL451534 | LANTALUCRATIN D | — | 1 | - |
| CHEMBL487398 | LANTALUCRATIN F | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL15192 | LAPACHONE | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL448558 | LANTALUCRATIN B | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL221630 | DEHYDROISO-ALPHA-LAPACHONE | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL510369 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL447062 | LANTALUCRATIN A | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL470256 | LANTALUCRATIN C | IC50 | = | 4900.0 | nM | 5.31 |
| CHEMBL487397 | LANTALUCRATIN E | IC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL451534 | LANTALUCRATIN D | IC50 | > | 10000.0 | nM | - |
| CHEMBL487398 | LANTALUCRATIN F | IC50 | > | 10000.0 | nM | - |