Assay Detail
Binding
CHEMBL1002916
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Binding affinity to 2GGG sequence of human telomeric DNA assessed as intramolecular folding leading to G-quadruplex formation at 25 degC after 30 mins by electrophoretic mobility shift assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Perylene side chains modulate G-quadruplex conformation in biologically relevant DNA sequences.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 5 | 4.90 | 5.42 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL225205 | — | — | 1 | 5.42 |
| CHEMBL225001 | — | — | 1 | 5.40 |
| CHEMBL224754 | — | — | 1 | 4.92 |
| CHEMBL224755 | — | — | 1 | 4.70 |
| CHEMBL359594 | — | — | 1 | 4.05 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL225205 | — | EC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL225001 | — | EC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL224754 | — | EC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL224755 | — | EC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL359594 | — | EC50 | = | 90000.0 | nM | 4.05 |