Assay Detail
Binding
CHEMBL1002944
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Inhibition of MMP2
40
Total Activities
40
Compounds Tested
3
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
Specific targeting of metzincin family members with small-molecule inhibitors: progress toward a multifarious challenge.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 21 | 6.52 | 7.86 |
| IC50 | 18 | 6.41 | 8.40 |
| Activity | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL40143 | — | — | 1 | 8.40 |
| CHEMBL181244 | — | — | 1 | 7.92 |
| CHEMBL483857 | — | — | 1 | 7.86 |
| CHEMBL445971 | — | — | 1 | 7.80 |
| CHEMBL447457 | — | — | 1 | 7.52 |
| CHEMBL434567 | — | — | 1 | 7.46 |
| CHEMBL520785 | — | — | 1 | 7.34 |
| CHEMBL485492 | — | — | 1 | 6.96 |
| CHEMBL497772 | — | — | 1 | 6.87 |
| CHEMBL507420 | — | — | 1 | 6.72 |
| CHEMBL209970 | — | — | 1 | 6.45 |
| CHEMBL251917 | — | — | 1 | 6.28 |
| CHEMBL484262 | — | — | 1 | 6.18 |
| CHEMBL503231 | — | — | 1 | 6.12 |
| CHEMBL98044 | — | — | 1 | 6.05 |
| CHEMBL399096 | — | — | 1 | 6.02 |
| CHEMBL402747 | — | — | 1 | 5.89 |
| CHEMBL117225 | — | — | 1 | 5.75 |
| CHEMBL148169 | — | — | 1 | 5.69 |
| CHEMBL395880 | — | — | 1 | 5.66 |
| CHEMBL270083 | — | — | 1 | 5.40 |
| CHEMBL24398 | — | — | 1 | 5.20 |
| CHEMBL50228 | — | — | 1 | 5.09 |
| CHEMBL250266 | — | — | 1 | 4.47 |
| CHEMBL389020 | — | — | 1 | - |
| CHEMBL508461 | — | — | 1 | - |
| CHEMBL523956 | — | — | 1 | - |
| CHEMBL491643 | — | — | 1 | - |
| CHEMBL497985 | — | — | 1 | - |
| CHEMBL318252 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL40143 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL181244 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL483857 | — | Ki | = | 13.9 | nM | 7.86 |
| CHEMBL445971 | — | Ki | = | 16.0 | nM | 7.80 |
| CHEMBL447457 | — | Ki | = | 30.0 | nM | 7.52 |
| CHEMBL434567 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL520785 | — | Ki | = | 46.0 | nM | 7.34 |
| CHEMBL485492 | — | Ki | = | 110.0 | nM | 6.96 |
| CHEMBL497772 | — | IC50 | = | 135.0 | nM | 6.87 |
| CHEMBL507420 | — | Ki | = | 192.0 | nM | 6.72 |
| CHEMBL209970 | — | IC50 | = | 355.0 | nM | 6.45 |
| CHEMBL251917 | — | IC50 | = | 529.0 | nM | 6.28 |
| CHEMBL484262 | — | IC50 | = | 664.0 | nM | 6.18 |
| CHEMBL503231 | — | IC50 | = | 750.0 | nM | 6.12 |
| CHEMBL98044 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL399096 | — | IC50 | = | 960.0 | nM | 6.02 |
| CHEMBL402747 | — | Ki | = | 1300.0 | nM | 5.89 |
| CHEMBL117225 | — | IC50 | = | 1790.0 | nM | 5.75 |
| CHEMBL148169 | — | Ki | = | 2050.0 | nM | 5.69 |
| CHEMBL395880 | — | Ki | = | 2170.0 | nM | 5.66 |
| CHEMBL270083 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL24398 | — | Ki | = | 6300.0 | nM | 5.20 |
| CHEMBL50228 | — | Ki | = | 8100.0 | nM | 5.09 |
| CHEMBL250266 | — | IC50 | = | 34200.0 | nM | 4.47 |
| CHEMBL270050 | — | Activity | - | — | - | |
| CHEMBL325163 | — | Ki | > | 2000.0 | nM | - |
| CHEMBL108494 | — | Ki | > | 15000.0 | nM | - |
| CHEMBL489603 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL496527 | — | Ki | > | 3333.0 | nM | - |
| CHEMBL207305 | — | Ki | > | 3333.0 | nM | - |
| CHEMBL495502 | — | Ki | > | 3000.0 | nM | - |
| CHEMBL253275 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL402393 | — | Ki | > | 3333.0 | nM | - |
| CHEMBL228320 | — | Ki | > | 3333.0 | nM | - |
| CHEMBL318252 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL497985 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL491643 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL523956 | — | Ki | > | 3000.0 | nM | - |
| CHEMBL508461 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL389020 | — | Ki | > | 100000.0 | nM | - |