Assay Detail
Binding
CHEMBL1002945
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Inhibition of MMP3
33
Total Activities
33
Compounds Tested
3
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
Specific targeting of metzincin family members with small-molecule inhibitors: progress toward a multifarious challenge.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 7.05 | 9.00 |
| Ki | 16 | 5.83 | 7.40 |
| Activity | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL251917 | — | — | 1 | 9.00 |
| CHEMBL503231 | — | — | 1 | 8.68 |
| CHEMBL117225 | — | — | 1 | 8.23 |
| CHEMBL489603 | — | — | 1 | 7.72 |
| CHEMBL250266 | — | — | 1 | 7.64 |
| CHEMBL507420 | — | — | 1 | 7.40 |
| CHEMBL40143 | — | — | 1 | 7.38 |
| CHEMBL497772 | — | — | 1 | 7.09 |
| CHEMBL207305 | — | — | 1 | 7.09 |
| CHEMBL148169 | — | — | 1 | 6.85 |
| CHEMBL98044 | — | — | 1 | 6.70 |
| CHEMBL508461 | — | — | 1 | 6.41 |
| CHEMBL495502 | — | — | 1 | 6.12 |
| CHEMBL434567 | — | — | 1 | 5.45 |
| CHEMBL445971 | — | — | 1 | 5.44 |
| CHEMBL181244 | — | — | 1 | 5.35 |
| CHEMBL318252 | — | — | 1 | 5.00 |
| CHEMBL520785 | — | — | 1 | 5.00 |
| CHEMBL485492 | — | — | 1 | 4.91 |
| CHEMBL50228 | — | — | 1 | 4.87 |
| CHEMBL483857 | — | — | 1 | 4.82 |
| CHEMBL497985 | — | — | 1 | - |
| CHEMBL491643 | — | — | 1 | - |
| CHEMBL523956 | — | — | 1 | - |
| CHEMBL389020 | — | — | 1 | - |
| CHEMBL26913 | — | — | 1 | - |
| CHEMBL270083 | — | — | 1 | - |
| CHEMBL270050 | — | — | 1 | - |
| CHEMBL325163 | — | — | 1 | - |
| CHEMBL253275 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL251917 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL503231 | — | IC50 | = | 2.1 | nM | 8.68 |
| CHEMBL117225 | — | IC50 | = | 5.9 | nM | 8.23 |
| CHEMBL489603 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL250266 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL507420 | — | Ki | = | 40.0 | nM | 7.40 |
| CHEMBL40143 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL497772 | — | IC50 | = | 81.0 | nM | 7.09 |
| CHEMBL207305 | — | Ki | = | 82.0 | nM | 7.09 |
| CHEMBL148169 | — | Ki | = | 141.0 | nM | 6.85 |
| CHEMBL98044 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL508461 | — | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL495502 | — | Ki | = | 762.0 | nM | 6.12 |
| CHEMBL434567 | — | IC50 | = | 3560.0 | nM | 5.45 |
| CHEMBL445971 | — | Ki | = | 3600.0 | nM | 5.44 |
| CHEMBL181244 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL318252 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL520785 | — | Ki | = | 10000.0 | nM | 5.00 |
| CHEMBL485492 | — | Ki | = | 12200.0 | nM | 4.91 |
| CHEMBL50228 | — | Ki | = | 13500.0 | nM | 4.87 |
| CHEMBL483857 | — | Ki | = | 15000.0 | nM | 4.82 |
| CHEMBL497985 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL491643 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL523956 | — | Ki | > | 4500.0 | nM | - |
| CHEMBL389020 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL26913 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL270083 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL270050 | — | Activity | - | — | - | |
| CHEMBL325163 | — | Ki | > | 2000.0 | nM | - |
| CHEMBL253275 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL402393 | — | Ki | > | 4501.0 | nM | - |
| CHEMBL395880 | — | Ki | > | 4500.0 | nM | - |
| CHEMBL228320 | — | Ki | > | 4501.0 | nM | - |