Assay Detail
Binding
CHEMBL1002946
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Inhibition of MMP8
20
Total Activities
20
Compounds Tested
3
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
Specific targeting of metzincin family members with small-molecule inhibitors: progress toward a multifarious challenge.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 13 | 6.40 | 7.77 |
| IC50 | 6 | 6.83 | 7.46 |
| Activity | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL50228 | — | — | 1 | 7.77 |
| CHEMBL484261 | — | — | 1 | 7.46 |
| CHEMBL447457 | — | — | 1 | 7.41 |
| CHEMBL497772 | — | — | 1 | 7.38 |
| CHEMBL24398 | — | — | 1 | 6.77 |
| CHEMBL98044 | — | — | 1 | 6.70 |
| CHEMBL325163 | — | — | 1 | 6.70 |
| CHEMBL148169 | — | — | 1 | 6.59 |
| CHEMBL507420 | — | — | 1 | 6.57 |
| CHEMBL508461 | — | — | 1 | 5.77 |
| CHEMBL495502 | — | — | 1 | 5.69 |
| CHEMBL402747 | — | — | 1 | 5.57 |
| CHEMBL262758 | — | — | 1 | 4.52 |
| CHEMBL270083 | — | — | 1 | - |
| CHEMBL108494 | — | — | 1 | - |
| CHEMBL270050 | — | — | 1 | - |
| CHEMBL207305 | — | — | 1 | - |
| CHEMBL253275 | — | — | 1 | - |
| CHEMBL402393 | — | — | 1 | - |
| CHEMBL318252 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL50228 | — | Ki | = | 17.0 | nM | 7.77 |
| CHEMBL484261 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL447457 | — | Ki | = | 38.9 | nM | 7.41 |
| CHEMBL497772 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL24398 | — | Ki | = | 171.0 | nM | 6.77 |
| CHEMBL98044 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL325163 | — | Ki | = | 200.0 | nM | 6.70 |
| CHEMBL148169 | — | Ki | = | 257.0 | nM | 6.59 |
| CHEMBL507420 | — | Ki | = | 271.0 | nM | 6.57 |
| CHEMBL508461 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL495502 | — | Ki | = | 2050.0 | nM | 5.69 |
| CHEMBL402747 | — | Ki | = | 2700.0 | nM | 5.57 |
| CHEMBL262758 | — | Ki | = | 30000.0 | nM | 4.52 |
| CHEMBL270083 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL108494 | — | Ki | > | 15000.0 | nM | - |
| CHEMBL270050 | — | Activity | - | — | - | |
| CHEMBL207305 | — | Ki | > | 3100.0 | nM | - |
| CHEMBL253275 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL402393 | — | Ki | > | 3058.0 | nM | - |
| CHEMBL318252 | — | IC50 | > | 100000.0 | nM | - |