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Assay Detail

CHEMBL1002947

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Binding
Inhibition of MMP13
31
Total Activities
31
Compounds Tested
2
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Intermediate

Target

Collagenase 3 (CHEMBL280)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Specific targeting of metzincin family members with small-molecule inhibitors: progress toward a multifarious challenge.
Georgiadis D, Yiotakis A.
Bioorg Med Chem (2008) 16 : 8781 -8794
PubMed 18790648 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 18 6.96 9.44
Ki 13 6.05 7.80

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL222077 1 9.44
CHEMBL496942 1 9.17
CHEMBL497772 1 8.74
CHEMBL270050 1 8.17
CHEMBL447457 1 7.80
CHEMBL71645 1 7.75
CHEMBL409536 1 7.52
CHEMBL507420 1 7.31
CHEMBL117225 1 7.14
CHEMBL484261 1 7.02
CHEMBL209970 1 6.64
CHEMBL508461 1 6.57
CHEMBL98044 1 6.40
CHEMBL325163 1 6.18
CHEMBL399096 1 5.93
CHEMBL148169 1 5.85
CHEMBL402747 1 5.77
CHEMBL484262 1 5.64
CHEMBL250266 1 5.64
CHEMBL228320 1 5.37
CHEMBL468900 1 5.18
CHEMBL318252 1 4.40
CHEMBL389020 1 4.04
CHEMBL108494 1 -
CHEMBL270083 1 -
CHEMBL253275 1 -
CHEMBL402393 1 -
CHEMBL495502 1 -
CHEMBL523956 1 -
CHEMBL401435 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL222077 IC50 = 0.36 nM 9.44
CHEMBL496942 IC50 = 0.67 nM 9.17
CHEMBL497772 IC50 = 1.8 nM 8.74
CHEMBL270050 IC50 = 6.72 nM 8.17
CHEMBL447457 Ki = 15.7 nM 7.80
CHEMBL71645 IC50 = 18.0 nM 7.75
CHEMBL409536 IC50 = 30.0 nM 7.52
CHEMBL507420 Ki = 49.0 nM 7.31
CHEMBL117225 IC50 = 73.0 nM 7.14
CHEMBL484261 IC50 = 96.0 nM 7.02
CHEMBL209970 IC50 = 230.0 nM 6.64
CHEMBL508461 IC50 = 270.0 nM 6.57
CHEMBL98044 IC50 = 400.0 nM 6.40
CHEMBL325163 Ki = 653.0 nM 6.18
CHEMBL399096 IC50 = 1170.0 nM 5.93
CHEMBL148169 Ki = 1417.0 nM 5.85
CHEMBL402747 Ki = 1700.0 nM 5.77
CHEMBL484262 IC50 = 2277.0 nM 5.64
CHEMBL250266 IC50 = 2300.0 nM 5.64
CHEMBL228320 Ki = 4314.0 nM 5.37
CHEMBL468900 IC50 = 6600.0 nM 5.18
CHEMBL318252 IC50 = 40000.0 nM 4.40
CHEMBL389020 Ki = 91000.0 nM 4.04
CHEMBL108494 Ki > 15000.0 nM -
CHEMBL270083 IC50 > 100000.0 nM -
CHEMBL253275 Ki > 10000.0 nM -
CHEMBL402393 Ki > 5025.0 nM -
CHEMBL495502 Ki > 5000.0 nM -
CHEMBL523956 Ki > 5000.0 nM -
CHEMBL401435 IC50 > 100000.0 nM -
CHEMBL207305 Ki > 5025.0 nM -