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Assay Detail

CHEMBL1002948

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Binding
Inhibition of MMP7
19
Total Activities
19
Compounds Tested
3
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Intermediate

Target

Matrilysin (CHEMBL4073)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Specific targeting of metzincin family members with small-molecule inhibitors: progress toward a multifarious challenge.
Georgiadis D, Yiotakis A.
Bioorg Med Chem (2008) 16 : 8781 -8794
PubMed 18790648 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 12 5.82 7.60
IC50 6 5.99 6.02
Activity 1 - -

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL207305 1 7.60
CHEMBL148169 1 6.59
CHEMBL507420 1 6.20
CHEMBL325163 1 6.08
CHEMBL484261 1 6.02
CHEMBL497772 1 5.96
CHEMBL485492 1 4.41
CHEMBL483857 1 4.02
CHEMBL402393 1 -
CHEMBL253275 1 -
CHEMBL270050 1 -
CHEMBL445971 1 -
CHEMBL40143 1 -
CHEMBL181244 1 -
CHEMBL395880 1 -
CHEMBL228320 1 -
CHEMBL497985 1 -
CHEMBL402747 1 -
CHEMBL434567 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL207305 Ki = 25.0 nM 7.60
CHEMBL148169 Ki = 259.0 nM 6.59
CHEMBL507420 Ki = 626.0 nM 6.20
CHEMBL325163 Ki = 834.0 nM 6.08
CHEMBL484261 IC50 = 961.0 nM 6.02
CHEMBL497772 IC50 = 1100.0 nM 5.96
CHEMBL485492 Ki = 39000.0 nM 4.41
CHEMBL483857 Ki = 96000.0 nM 4.02
CHEMBL402393 Ki > 6368.0 nM -
CHEMBL253275 Ki > 10000.0 nM -
CHEMBL270050 Activity - -
CHEMBL445971 Ki = 295000.0 nM -
CHEMBL40143 IC50 > 10000.0 nM -
CHEMBL181244 IC50 > 50000.0 nM -
CHEMBL395880 Ki > 6370.0 nM -
CHEMBL228320 Ki > 636.0 nM -
CHEMBL497985 IC50 > 5000.0 nM -
CHEMBL402747 Ki > 2500.0 nM -
CHEMBL434567 IC50 > 5000.0 nM -