Assay Detail
Functional
CHEMBL1002998
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Inhibition of KCl-induced tonic contraction in Beagle dog detrusor muscle strips preincubated for 15 mins before KCl challenge
21
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Canis lupus familiaris |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Discovery of highly potent and selective biphenylacylsulfonamide-based beta3-adrenergic receptor agonists and evaluation of physical properties as potential overactive bladder therapies: part 5.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 21 | 8.28 | 8.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL471060 | — | — | 1 | 8.92 |
| CHEMBL452134 | — | — | 1 | 8.90 |
| CHEMBL515397 | — | — | 2 | 8.90 |
| CHEMBL492401 | — | — | 1 | 8.90 |
| CHEMBL469821 | — | — | 1 | 8.59 |
| CHEMBL473702 | — | — | 1 | 8.44 |
| CHEMBL446806 | — | — | 2 | 8.40 |
| CHEMBL488224 | — | — | 2 | 8.30 |
| CHEMBL271945 | — | — | 1 | 8.17 |
| CHEMBL491726 | — | — | 1 | 8.10 |
| CHEMBL470292 | — | — | 1 | 8.10 |
| CHEMBL270026 | — | — | 1 | 8.06 |
| CHEMBL271574 | — | — | 1 | 7.96 |
| CHEMBL470856 | — | — | 1 | 7.94 |
| CHEMBL469395 | — | — | 2 | 7.90 |
| CHEMBL445481 | — | — | 1 | 7.21 |
| CHEMBL469396 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL471060 | — | EC50 | = | 1.2 | nM | 8.92 |
| CHEMBL452134 | — | EC50 | = | 1.259 | nM | 8.90 |
| CHEMBL492401 | — | EC50 | = | 1.259 | nM | 8.90 |
| CHEMBL515397 | — | EC50 | = | 1.259 | nM | 8.90 |
| CHEMBL469821 | — | EC50 | = | 2.6 | nM | 8.59 |
| CHEMBL473702 | — | EC50 | = | 3.6 | nM | 8.44 |
| CHEMBL446806 | — | EC50 | = | 3.981 | nM | 8.40 |
| CHEMBL446806 | — | EC50 | = | 4.4 | nM | 8.36 |
| CHEMBL488224 | — | EC50 | = | 5.012 | nM | 8.30 |
| CHEMBL271945 | — | EC50 | = | 6.8 | nM | 8.17 |
| CHEMBL491726 | — | EC50 | = | 7.943 | nM | 8.10 |
| CHEMBL470292 | — | EC50 | = | 7.943 | nM | 8.10 |
| CHEMBL270026 | — | EC50 | = | 8.7 | nM | 8.06 |
| CHEMBL271574 | — | EC50 | = | 11.0 | nM | 7.96 |
| CHEMBL470856 | — | EC50 | = | 11.4 | nM | 7.94 |
| CHEMBL469395 | — | EC50 | = | 12.59 | nM | 7.90 |
| CHEMBL488224 | — | EC50 | = | 14.1 | nM | 7.85 |
| CHEMBL445481 | — | EC50 | = | 62.0 | nM | 7.21 |
| CHEMBL469396 | — | EC50 | - | — | - | |
| CHEMBL469395 | — | EC50 | > | 50.0 | nM | - |
| CHEMBL515397 | — | EC50 | - | — | - |