Assay Detail
Binding
CHEMBL1003158
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Inhibition of Cdc25A (336-523) expressed in Escherichia coli
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
Discovery of novel Cdc25 phosphatase inhibitors with micromolar activity based on the structure-based virtual screening.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.49 | 6.09 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL459929 | — | — | 1 | 6.09 |
| CHEMBL401371 | — | — | 1 | 5.48 |
| CHEMBL400144 | — | — | 1 | 5.48 |
| CHEMBL493077 | — | — | 1 | 5.39 |
| CHEMBL523844 | — | — | 1 | 5.37 |
| CHEMBL92659 | — | — | 1 | 5.34 |
| CHEMBL429095 | — | — | 1 | 5.26 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL459929 | — | IC50 | = | 820.0 | nM | 6.09 |
| CHEMBL401371 | — | IC50 | = | 3310.0 | nM | 5.48 |
| CHEMBL400144 | — | IC50 | = | 3280.0 | nM | 5.48 |
| CHEMBL493077 | — | IC50 | = | 4070.0 | nM | 5.39 |
| CHEMBL523844 | — | IC50 | = | 4270.0 | nM | 5.37 |
| CHEMBL92659 | — | IC50 | = | 4560.0 | nM | 5.34 |
| CHEMBL429095 | — | IC50 | = | 5490.0 | nM | 5.26 |