Assay Detail
Binding
CHEMBL1003161
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Binding affinity to Cdc25A (336-523) expressed in Escherichia coli by steady-state kinetic assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
Discovery of novel Cdc25 phosphatase inhibitors with micromolar activity based on the structure-based virtual screening.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 4.58 | 4.69 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL493077 | — | — | 1 | 4.69 |
| CHEMBL523844 | — | — | 1 | 4.67 |
| CHEMBL401371 | — | — | 1 | 4.54 |
| CHEMBL459929 | — | — | 1 | 4.43 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL493077 | — | Ki | = | 20350.0 | nM | 4.69 |
| CHEMBL523844 | — | Ki | = | 21370.0 | nM | 4.67 |
| CHEMBL401371 | — | Ki | = | 29160.0 | nM | 4.54 |
| CHEMBL459929 | — | Ki | = | 37470.0 | nM | 4.43 |