Assay Detail
Binding
CHEMBL1003424
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Inhibition of NADH-oxidase activity of electron transport protein complex 1 in submitochondrial particles of bovine heart
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bos taurus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
10-Oximeguanacone, the first nitrogenated acetogenin derivative found to be a potent inhibitor of mitochondrial complex I.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 9.28 | 9.49 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL145449 | BULLANIN | — | 1 | 9.49 |
| CHEMBL502162 | ROLLIMEMBRIN | — | 1 | 9.48 |
| CHEMBL141607 | — | — | 1 | 9.47 |
| CHEMBL66691 | MOTRILIN | — | 1 | 9.39 |
| CHEMBL453496 | rolliniastatin-2 | — | 1 | 9.29 |
| CHEMBL145455 | — | — | 1 | 9.02 |
| CHEMBL145624 | GUANACONE | — | 1 | 8.82 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL145449 | BULLANIN | IC50 | = | 0.32 | nM | 9.49 |
| CHEMBL502162 | ROLLIMEMBRIN | IC50 | = | 0.33 | nM | 9.48 |
| CHEMBL141607 | — | IC50 | = | 0.34 | nM | 9.47 |
| CHEMBL66691 | MOTRILIN | IC50 | = | 0.41 | nM | 9.39 |
| CHEMBL453496 | rolliniastatin-2 | IC50 | = | 0.51 | nM | 9.29 |
| CHEMBL145455 | — | IC50 | = | 0.95 | nM | 9.02 |
| CHEMBL145624 | GUANACONE | IC50 | = | 1.52 | nM | 8.82 |