Assay Detail
Binding
CHEMBL1003425
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Inhibition of NADH-ubiquinone oxidoreductase activity of electron transport protein complex 1 in submitochondrial particles of bovine heart
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bos taurus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
10-Oximeguanacone, the first nitrogenated acetogenin derivative found to be a potent inhibitor of mitochondrial complex I.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 9.04 | 9.36 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL145449 | BULLANIN | — | 1 | 9.36 |
| CHEMBL453496 | rolliniastatin-2 | — | 1 | 9.21 |
| CHEMBL141607 | — | — | 1 | 9.17 |
| CHEMBL66691 | MOTRILIN | — | 1 | 9.09 |
| CHEMBL502162 | ROLLIMEMBRIN | — | 1 | 9.08 |
| CHEMBL145455 | — | — | 1 | 8.72 |
| CHEMBL145624 | GUANACONE | — | 1 | 8.68 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL145449 | BULLANIN | IC50 | = | 0.44 | nM | 9.36 |
| CHEMBL453496 | rolliniastatin-2 | IC50 | = | 0.61 | nM | 9.21 |
| CHEMBL141607 | — | IC50 | = | 0.68 | nM | 9.17 |
| CHEMBL66691 | MOTRILIN | IC50 | = | 0.81 | nM | 9.09 |
| CHEMBL502162 | ROLLIMEMBRIN | IC50 | = | 0.83 | nM | 9.08 |
| CHEMBL145455 | — | IC50 | = | 1.9 | nM | 8.72 |
| CHEMBL145624 | GUANACONE | IC50 | = | 2.07 | nM | 8.68 |