Assay Detail
Functional
CHEMBL1003534
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Cytotoxicity against human KB cells
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | KB |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Three new cryptophycins from Nostoc sp. GSV 224.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 8.05 | 9.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL502895 | CRYPTOPHYCIN 16 | — | 1 | 9.52 |
| CHEMBL452431 | CRYPTOPHYCIN 176 | — | 1 | 8.89 |
| CHEMBL13529 | CRYPTOPHYCIN 3 | — | 1 | 8.72 |
| CHEMBL506269 | CRYPTOPHYCIN 175 | — | 1 | 7.00 |
| CHEMBL492459 | CRYPTOPHYCIN 46 | — | 1 | 6.12 |
| CHEMBL441018 | CRYPTOPHYCIN A | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL502895 | CRYPTOPHYCIN 16 | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL452431 | CRYPTOPHYCIN 176 | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL13529 | CRYPTOPHYCIN 3 | IC50 | = | 1.9 | nM | 8.72 |
| CHEMBL506269 | CRYPTOPHYCIN 175 | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL492459 | CRYPTOPHYCIN 46 | IC50 | = | 750.0 | nM | 6.12 |
| CHEMBL441018 | CRYPTOPHYCIN A | IC50 | = | 0.0092 | nM | - |