Assay Detail
Binding
CHEMBL1003623
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Inhibition of MMP13
8
Total Activities
8
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
Current perspective of TACE inhibitors: a review.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 8.44 | 10.00 |
| Ki | 1 | 7.26 | 7.26 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL516206 | — | — | 1 | 10.00 |
| CHEMBL207729 | — | — | 1 | 8.52 |
| CHEMBL491287 | — | — | 1 | 8.52 |
| CHEMBL290952 | — | — | 1 | 8.40 |
| CHEMBL34418 | — | — | 1 | 8.00 |
| CHEMBL18614 | — | — | 1 | 7.96 |
| CHEMBL183924 | — | — | 1 | 7.70 |
| CHEMBL100570 | — | — | 1 | 7.26 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL516206 | — | IC50 | = | 0.1 | nM | 10.00 |
| CHEMBL207729 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL491287 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL290952 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL34418 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL18614 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL183924 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL100570 | — | Ki | = | 55.0 | nM | 7.26 |