Assay Detail
Binding
CHEMBL1003658
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Inhibition of 5LOX in bovine polymorphonuclear leucocytes assessed as leukotriene B4 formation
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bos taurus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Diaryl-dithiolanes and -isothiazoles: COX-1/COX-2 and 5-LOX-inhibitory, *OH scavenging and anti-adhesive activities.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 25 | 5.02 | 6.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL300982 | LICOFELONE | 2.0 | 1 | 6.72 |
| CHEMBL52 | NORDIHYDROGUAIARETIC ACID | — | 1 | 6.00 |
| CHEMBL489701 | — | — | 1 | 5.52 |
| CHEMBL472722 | — | — | 1 | 5.22 |
| CHEMBL514950 | — | — | 1 | 5.10 |
| CHEMBL491477 | — | — | 1 | 5.05 |
| CHEMBL171646 | — | — | 1 | 5.00 |
| CHEMBL489899 | — | — | 1 | 5.00 |
| CHEMBL473946 | — | — | 1 | 4.70 |
| CHEMBL522624 | — | — | 1 | 4.70 |
| CHEMBL489898 | — | — | 1 | 4.70 |
| CHEMBL489702 | — | — | 1 | 4.70 |
| CHEMBL491089 | — | — | 1 | 4.30 |
| CHEMBL524133 | — | — | 1 | 4.30 |
| CHEMBL490889 | — | — | 1 | 4.30 |
| CHEMBL522267 | — | — | 1 | - |
| CHEMBL472721 | — | — | 1 | - |
| CHEMBL515547 | — | — | 1 | - |
| CHEMBL475347 | — | — | 1 | - |
| CHEMBL475545 | — | — | 1 | - |
| CHEMBL504541 | — | — | 1 | - |
| CHEMBL490292 | — | — | 1 | - |
| CHEMBL491272 | — | — | 1 | - |
| CHEMBL139 | DICLOFENAC | 4.0 | 1 | - |
| CHEMBL491090 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL300982 | LICOFELONE | IC50 | = | 189.0 | nM | 6.72 |
| CHEMBL52 | NORDIHYDROGUAIARETIC ACID | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL489701 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL472722 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL514950 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL491477 | — | IC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL171646 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL489899 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL473946 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL522624 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL489898 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL489702 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL491089 | — | IC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL524133 | — | IC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL490889 | — | IC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL522267 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL472721 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL515547 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL475347 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL475545 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL504541 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL490292 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL491272 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL139 | DICLOFENAC | IC50 | > | 50000.0 | nM | - |
| CHEMBL491090 | — | IC50 | > | 50000.0 | nM | - |