Assay Detail
Binding
CHEMBL1003726
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human recombinant MAO-A assessed as hydrogen peroxide production
6
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Chalcones: a valid scaffold for monoamine oxidases inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.66 | 8.35 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL8706 | CLORGILINE | 2.0 | 1 | 8.35 |
| CHEMBL139679 | — | — | 2 | 5.31 |
| CHEMBL92401 | IPRONIAZID | 2.0 | 1 | 5.18 |
| CHEMBL972 | SELEGILINE | 4.0 | 1 | 4.17 |
| CHEMBL86304 | MOCLOBEMIDE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL8706 | CLORGILINE | IC50 | = | 4.5 | nM | 8.35 |
| CHEMBL139679 | — | IC50 | = | 4897.79 | nM | 5.31 |
| CHEMBL139679 | — | IC50 | = | 4950.0 | nM | 5.30 |
| CHEMBL92401 | IPRONIAZID | IC50 | = | 6560.0 | nM | 5.18 |
| CHEMBL972 | SELEGILINE | IC50 | = | 67250.0 | nM | 4.17 |
| CHEMBL86304 | MOCLOBEMIDE | IC50 | = | 361380.0 | nM | - |