Assay Detail
Binding
CHEMBL1003729
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Inhibition of human recombinant MAO-B assessed as hydrogen peroxide production
19
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Chalcones: a valid scaffold for monoamine oxidases inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 6.59 | 8.36 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL406861 | — | — | 2 | 8.36 |
| CHEMBL139679 | — | — | 2 | 8.30 |
| CHEMBL972 | SELEGILINE | 4.0 | 1 | 7.70 |
| CHEMBL7531 | — | — | 1 | 7.51 |
| CHEMBL489719 | — | — | 1 | 7.27 |
| CHEMBL490752 | — | — | 1 | 7.15 |
| CHEMBL241861 | — | — | 1 | 6.80 |
| CHEMBL489720 | — | — | 1 | 6.35 |
| CHEMBL490923 | — | — | 1 | 6.33 |
| CHEMBL490922 | — | — | 1 | 6.30 |
| CHEMBL491888 | — | — | 1 | 5.99 |
| CHEMBL489718 | — | — | 1 | 5.90 |
| CHEMBL7976 | CHALCONE | — | 1 | 5.85 |
| CHEMBL92401 | IPRONIAZID | 2.0 | 1 | 5.12 |
| CHEMBL450771 | CORDOIN | — | 2 | 4.73 |
| CHEMBL8706 | CLORGILINE | 2.0 | 1 | 4.21 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL406861 | — | IC50 | = | 4.4 | nM | 8.36 |
| CHEMBL406861 | — | IC50 | = | 4.467 | nM | 8.35 |
| CHEMBL139679 | — | IC50 | = | 5.012 | nM | 8.30 |
| CHEMBL139679 | — | IC50 | = | 5.1 | nM | 8.29 |
| CHEMBL972 | SELEGILINE | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL7531 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL489719 | — | IC50 | = | 54.0 | nM | 7.27 |
| CHEMBL490752 | — | IC50 | = | 71.0 | nM | 7.15 |
| CHEMBL241861 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL489720 | — | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL490923 | — | IC50 | = | 470.0 | nM | 6.33 |
| CHEMBL490922 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL491888 | — | IC50 | = | 1030.0 | nM | 5.99 |
| CHEMBL489718 | — | IC50 | = | 1250.0 | nM | 5.90 |
| CHEMBL7976 | CHALCONE | IC50 | = | 1410.0 | nM | 5.85 |
| CHEMBL92401 | IPRONIAZID | IC50 | = | 7540.0 | nM | 5.12 |
| CHEMBL450771 | CORDOIN | IC50 | = | 18760.0 | nM | 4.73 |
| CHEMBL450771 | CORDOIN | IC50 | = | 18620.87 | nM | 4.73 |
| CHEMBL8706 | CLORGILINE | IC50 | = | 61350.0 | nM | 4.21 |