Assay Detail
Binding
CHEMBL1003960
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Inhibition of wild-type HIV1 integrase 3'-processing activity using [32P]-labeled linear oligonucleotide substrate by polyacrylamide gel electrophoresis
34
Total Activities
34
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Human immunodeficiency virus type 1 integrase (CHEMBL3471) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
Novel dimeric aryldiketo containing inhibitors of HIV-1 integrase: effects of the phenyl substituent and the linker orientation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 34 | 4.26 | 4.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL492770 | — | — | 1 | 4.72 |
| CHEMBL454190 | — | — | 1 | 4.64 |
| CHEMBL467380 | — | — | 1 | 4.58 |
| CHEMBL467149 | — | — | 1 | 4.26 |
| CHEMBL443890 | — | — | 1 | 4.25 |
| CHEMBL452223 | — | — | 1 | 4.04 |
| CHEMBL513666 | — | — | 1 | 4.04 |
| CHEMBL444974 | — | — | 1 | 4.03 |
| CHEMBL467361 | — | — | 1 | 4.00 |
| CHEMBL469071 | — | — | 1 | 4.00 |
| CHEMBL468235 | — | — | 1 | - |
| CHEMBL467360 | — | — | 1 | - |
| CHEMBL513321 | — | — | 1 | - |
| CHEMBL476930 | — | — | 1 | - |
| CHEMBL467381 | — | — | 1 | - |
| CHEMBL448880 | — | — | 1 | - |
| CHEMBL467351 | — | — | 1 | - |
| CHEMBL465864 | — | — | 1 | - |
| CHEMBL505776 | — | — | 1 | - |
| CHEMBL464340 | — | — | 1 | - |
| CHEMBL452876 | — | — | 1 | - |
| CHEMBL511423 | — | — | 1 | - |
| CHEMBL452111 | — | — | 1 | - |
| CHEMBL467159 | — | — | 1 | - |
| CHEMBL449221 | — | — | 1 | - |
| CHEMBL467169 | — | — | 1 | - |
| CHEMBL469069 | — | — | 1 | - |
| CHEMBL469070 | — | — | 1 | - |
| CHEMBL467389 | — | — | 1 | - |
| CHEMBL467359 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL492770 | — | IC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL454190 | — | IC50 | = | 23000.0 | nM | 4.64 |
| CHEMBL467380 | — | IC50 | = | 26000.0 | nM | 4.58 |
| CHEMBL467149 | — | IC50 | = | 55000.0 | nM | 4.26 |
| CHEMBL443890 | — | IC50 | = | 56000.0 | nM | 4.25 |
| CHEMBL452223 | — | IC50 | = | 91000.0 | nM | 4.04 |
| CHEMBL513666 | — | IC50 | = | 92000.0 | nM | 4.04 |
| CHEMBL444974 | — | IC50 | = | 94000.0 | nM | 4.03 |
| CHEMBL467361 | — | IC50 | = | 99000.0 | nM | 4.00 |
| CHEMBL469071 | — | IC50 | = | 99000.0 | nM | 4.00 |
| CHEMBL513321 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL468234 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL476930 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL467381 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL448880 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL467351 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL465864 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL505776 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL464340 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL502238 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL468233 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL512106 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL467360 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL468235 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL452876 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL511423 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL452111 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL467159 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL449221 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL467169 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL469069 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL469070 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL467389 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL467359 | — | IC50 | > | 100000.0 | nM | - |