Assay Detail
Functional
CHEMBL1003969
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Antiproliferative activity against human HT29 cells after 24 hrs of drug exposure followed by 48 hrs incubation in drug free media
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HT-29 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Sulfur-substituted naphthalimides as photoactivatable anticancer agents: DNA interaction, fluorescence imaging, and phototoxic effects in cultured tumor cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.56 | 6.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL233051 | — | — | 1 | 6.64 |
| CHEMBL467390 | — | — | 1 | 5.66 |
| CHEMBL467189 | — | — | 1 | 5.55 |
| CHEMBL455014 | — | — | 1 | 5.37 |
| CHEMBL467188 | — | — | 1 | 5.32 |
| CHEMBL512431 | — | — | 1 | 5.26 |
| CHEMBL20330 | — | — | 1 | 5.14 |
| CHEMBL466176 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL233051 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL467390 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL467189 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL455014 | — | IC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL467188 | — | IC50 | = | 4800.0 | nM | 5.32 |
| CHEMBL512431 | — | IC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL20330 | — | IC50 | = | 7200.0 | nM | 5.14 |
| CHEMBL466176 | — | IC50 | > | 50000.0 | nM | - |