Assay Detail
Binding
CHEMBL1004565
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of tubulin polymerization
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Synthesis and biological evaluation of 2-amino-3-(3',4',5'-trimethoxybenzoyl)-6-substituted-4,5,6,7-tetrahydrothieno[2,3-c]pyridine derivatives as antimitotic agents and inhibitors of tubulin polymerization.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.87 | 6.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL496320 | — | — | 1 | 6.22 |
| CHEMBL524986 | — | — | 1 | 6.22 |
| CHEMBL67 | COMBRETASTATIN A4 | -1.0 | 1 | 5.92 |
| CHEMBL447202 | — | — | 1 | 5.72 |
| CHEMBL189355 | — | — | 1 | 5.27 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL496320 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL524986 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL67 | COMBRETASTATIN A4 | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL447202 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL189355 | — | IC50 | = | 5400.0 | nM | 5.27 |