Assay Detail
Binding
CHEMBL1004728
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Inhibition of Escherichia coli DNA gyrase
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Escherichia coli |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Novel dual-targeting benzimidazole urea inhibitors of DNA gyrase and topoisomerase IV possessing potent antibacterial activity: intelligent design and evolution through the judicious use of structure-guided design and structure-activity relationships.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 22 | 7.26 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL519583 | — | — | 1 | 8.30 |
| CHEMBL487664 | — | — | 1 | 8.22 |
| CHEMBL36506 | NOVOBIOCIN | 4.0 | 1 | 7.85 |
| CHEMBL222348 | — | — | 1 | 7.82 |
| CHEMBL487832 | — | — | 1 | 7.75 |
| CHEMBL512701 | — | — | 1 | 7.70 |
| CHEMBL472009 | — | — | 1 | 7.48 |
| CHEMBL472010 | — | — | 1 | 7.21 |
| CHEMBL472524 | — | — | 1 | 7.09 |
| CHEMBL486646 | — | — | 1 | 6.92 |
| CHEMBL486645 | — | — | 1 | 6.89 |
| CHEMBL472525 | — | — | 1 | 6.40 |
| CHEMBL471145 | — | — | 1 | 4.70 |
| CHEMBL487851 | — | — | 1 | - |
| CHEMBL487852 | — | — | 1 | - |
| CHEMBL487663 | — | — | 1 | - |
| CHEMBL222333 | — | — | 1 | - |
| CHEMBL471319 | — | — | 1 | - |
| CHEMBL486831 | — | — | 1 | - |
| CHEMBL486832 | — | — | 1 | - |
| CHEMBL519397 | — | — | 1 | - |
| CHEMBL488699 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL519583 | — | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL487664 | — | Ki | = | 6.0 | nM | 8.22 |
| CHEMBL36506 | NOVOBIOCIN | Ki | = | 14.0 | nM | 7.85 |
| CHEMBL222348 | — | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL487832 | — | Ki | = | 18.0 | nM | 7.75 |
| CHEMBL512701 | — | Ki | = | 20.0 | nM | 7.70 |
| CHEMBL472009 | — | Ki | = | 33.0 | nM | 7.48 |
| CHEMBL472010 | — | Ki | = | 61.0 | nM | 7.21 |
| CHEMBL472524 | — | Ki | = | 81.0 | nM | 7.09 |
| CHEMBL486646 | — | Ki | = | 120.0 | nM | 6.92 |
| CHEMBL486645 | — | Ki | = | 130.0 | nM | 6.89 |
| CHEMBL472525 | — | Ki | = | 400.0 | nM | 6.40 |
| CHEMBL471145 | — | Ki | = | 20000.0 | nM | 4.70 |
| CHEMBL487851 | — | Ki | < | 4.0 | nM | - |
| CHEMBL487852 | — | Ki | < | 4.0 | nM | - |
| CHEMBL487663 | — | Ki | < | 4.0 | nM | - |
| CHEMBL222333 | — | Ki | < | 4.0 | nM | - |
| CHEMBL471319 | — | Ki | < | 4.0 | nM | - |
| CHEMBL486831 | — | Ki | < | 4.0 | nM | - |
| CHEMBL486832 | — | Ki | < | 4.0 | nM | - |
| CHEMBL519397 | — | Ki | < | 4.0 | nM | - |
| CHEMBL488699 | — | Ki | < | 4.0 | nM | - |