Assay Detail
Binding
CHEMBL1004869
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Inhibition of human recombinant cathepsin B after 10 mins
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Inhibition of the activation of multiple serine proteases with a cathepsin C inhibitor requires sustained exposure to prevent pro-enzyme processing.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 6.76 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL374508 | E-64 | — | 1 | 8.00 |
| CHEMBL477531 | — | — | 1 | 7.40 |
| CHEMBL518284 | — | — | 1 | 7.19 |
| CHEMBL400387 | — | — | 1 | 6.55 |
| CHEMBL222649 | — | — | 1 | 5.87 |
| CHEMBL450997 | — | — | 1 | 5.53 |
| CHEMBL448143 | — | — | 1 | - |
| CHEMBL478737 | — | — | 1 | - |
| CHEMBL516292 | — | — | 1 | - |
| CHEMBL1162477 | — | — | 1 | - |
| CHEMBL515494 | — | — | 1 | - |
| CHEMBL1162478 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL374508 | E-64 | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL477531 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL518284 | — | IC50 | = | 65.0 | nM | 7.19 |
| CHEMBL400387 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL222649 | — | IC50 | = | 1360.0 | nM | 5.87 |
| CHEMBL450997 | — | IC50 | = | 2940.0 | nM | 5.53 |
| CHEMBL448143 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL478737 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL516292 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL1162477 | — | IC50 | > | 3000.0 | nM | - |
| CHEMBL515494 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL1162478 | — | IC50 | - | — | - |