Assay Detail
Functional
CHEMBL1005024
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Agonist activity at turkey P2Y1 receptor expressed in human 1321N1 cells assessed as increase in intracellular calcium concentration by dual-excitation spectrofluorimetric analysis
7
Total Activities
5
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Meleagris gallopavo |
| Cell Type | 1321-N1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Identification of hydrolytically stable and selective P2Y(1) receptor agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 6.82 | 8.40 |
| Activity | 3 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL435402 | — | — | 1 | 8.40 |
| CHEMBL590527 | — | — | 1 | 7.10 |
| CHEMBL14830 | ADENOSINE DIPHOSPHATE | 0.5 | 1 | 7.00 |
| CHEMBL2448400 | — | — | 2 | 4.76 |
| CHEMBL2448399 | — | — | 2 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL435402 | — | EC50 | = | 4.0 | nM | 8.40 |
| CHEMBL590527 | — | EC50 | = | 80.0 | nM | 7.10 |
| CHEMBL14830 | ADENOSINE DIPHOSPHATE | EC50 | = | 100.0 | nM | 7.00 |
| CHEMBL2448400 | — | EC50 | = | 17200.0 | nM | 4.76 |
| CHEMBL2448399 | — | Activity | - | — | - | |
| CHEMBL2448400 | — | Activity | - | — | - | |
| CHEMBL2448399 | — | Activity | - | — | - |