Assay Detail
Binding
CHEMBL1005173
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Inhibition of human factor 12a
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Novel 3-carboxamide-coumarins as potent and selective FXIIa inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 27 | 4.83 | 6.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL521527 | — | — | 1 | 6.75 |
| CHEMBL521526 | — | — | 1 | 5.37 |
| CHEMBL493601 | — | — | 1 | 5.36 |
| CHEMBL444181 | — | — | 1 | 5.08 |
| CHEMBL494978 | — | — | 1 | 5.01 |
| CHEMBL494808 | — | — | 1 | 5.00 |
| CHEMBL495154 | — | — | 1 | 5.00 |
| CHEMBL523874 | — | — | 1 | 4.82 |
| CHEMBL274376 | — | — | 1 | 4.77 |
| CHEMBL494799 | — | — | 1 | 4.72 |
| CHEMBL522532 | — | — | 1 | 4.70 |
| CHEMBL494632 | — | — | 1 | 4.66 |
| CHEMBL495466 | — | — | 1 | 4.64 |
| CHEMBL494633 | — | — | 1 | 4.62 |
| CHEMBL495153 | — | — | 1 | 4.60 |
| CHEMBL522376 | — | — | 1 | 4.54 |
| CHEMBL495225 | — | — | 1 | 4.52 |
| CHEMBL494798 | — | — | 1 | 4.51 |
| CHEMBL495155 | — | — | 1 | 4.50 |
| CHEMBL502858 | — | — | 1 | 4.50 |
| CHEMBL495465 | — | — | 1 | 4.48 |
| CHEMBL494800 | — | — | 1 | 4.47 |
| CHEMBL494795 | — | — | 1 | 4.38 |
| CHEMBL493602 | — | — | 1 | - |
| CHEMBL493615 | — | — | 1 | - |
| CHEMBL495467 | — | — | 1 | - |
| CHEMBL13357 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL521527 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL521526 | — | IC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL493601 | — | IC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL444181 | — | IC50 | = | 8300.0 | nM | 5.08 |
| CHEMBL494978 | — | IC50 | = | 9800.0 | nM | 5.01 |
| CHEMBL494808 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL495154 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL523874 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL274376 | — | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL494799 | — | IC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL522532 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL494632 | — | IC50 | = | 22000.0 | nM | 4.66 |
| CHEMBL495466 | — | IC50 | = | 23000.0 | nM | 4.64 |
| CHEMBL494633 | — | IC50 | = | 24000.0 | nM | 4.62 |
| CHEMBL495153 | — | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL522376 | — | IC50 | = | 29000.0 | nM | 4.54 |
| CHEMBL495225 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL494798 | — | IC50 | = | 31000.0 | nM | 4.51 |
| CHEMBL495155 | — | IC50 | = | 32000.0 | nM | 4.50 |
| CHEMBL502858 | — | IC50 | = | 32000.0 | nM | 4.50 |
| CHEMBL495465 | — | IC50 | = | 33000.0 | nM | 4.48 |
| CHEMBL494800 | — | IC50 | = | 34000.0 | nM | 4.47 |
| CHEMBL494795 | — | IC50 | = | 42000.0 | nM | 4.38 |
| CHEMBL493602 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL493615 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL495467 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL13357 | — | IC50 | > | 50000.0 | nM | - |