Assay Detail
Binding
CHEMBL1005300
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Inhibition of human recombinant CA2 by stopped flow CO2 hydration assay
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Ligand-based and structure-based virtual screening to identify carbonic anhydrase IX inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 17 | 6.91 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL508489 | — | — | 1 | 8.30 |
| CHEMBL20 | ACETAZOLAMIDE | 4.0 | 1 | 7.92 |
| CHEMBL76956 | — | — | 1 | 7.68 |
| CHEMBL461601 | — | — | 1 | 7.29 |
| CHEMBL183945 | — | — | 1 | 7.08 |
| CHEMBL75620 | — | — | 1 | 7.08 |
| CHEMBL511186 | — | — | 1 | 7.00 |
| CHEMBL366069 | — | — | 1 | 6.97 |
| CHEMBL6784 | — | — | 1 | 6.96 |
| CHEMBL268809 | — | — | 1 | 6.90 |
| CHEMBL7087 | — | — | 1 | 6.80 |
| CHEMBL461791 | — | — | 1 | 6.58 |
| CHEMBL517746 | — | — | 1 | 6.48 |
| CHEMBL461963 | — | — | 1 | 6.42 |
| CHEMBL461964 | — | — | 1 | 6.19 |
| CHEMBL461600 | — | — | 1 | 6.18 |
| CHEMBL453731 | — | — | 1 | 5.58 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL508489 | — | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL20 | ACETAZOLAMIDE | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL76956 | — | Ki | = | 21.0 | nM | 7.68 |
| CHEMBL461601 | — | Ki | = | 51.0 | nM | 7.29 |
| CHEMBL183945 | — | Ki | = | 84.0 | nM | 7.08 |
| CHEMBL75620 | — | Ki | = | 84.0 | nM | 7.08 |
| CHEMBL511186 | — | Ki | = | 100.0 | nM | 7.00 |
| CHEMBL366069 | — | Ki | = | 106.0 | nM | 6.97 |
| CHEMBL6784 | — | Ki | = | 110.0 | nM | 6.96 |
| CHEMBL268809 | — | Ki | = | 125.0 | nM | 6.90 |
| CHEMBL7087 | — | Ki | = | 160.0 | nM | 6.80 |
| CHEMBL461791 | — | Ki | = | 265.0 | nM | 6.58 |
| CHEMBL517746 | — | Ki | = | 330.0 | nM | 6.48 |
| CHEMBL461963 | — | Ki | = | 380.0 | nM | 6.42 |
| CHEMBL461964 | — | Ki | = | 643.0 | nM | 6.19 |
| CHEMBL461600 | — | Ki | = | 660.0 | nM | 6.18 |
| CHEMBL453731 | — | Ki | = | 2610.0 | nM | 5.58 |