Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL1005301

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of human recombinant CA9 by stopped flow CO2 hydration assay
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Carbonic anhydrase 9 (CHEMBL3594)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Ligand-based and structure-based virtual screening to identify carbonic anhydrase IX inhibitors.
Thiry A, Ledecq M, Cecchi A, Frederick R, Dogné JM, Supuran CT, Wouters J, Masereel B.
Bioorg Med Chem (2009) 17 : 553 -557
PubMed 19097911 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 17 7.42 9.82

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL366069 1 9.82
CHEMBL183945 1 9.47
CHEMBL76956 1 9.10
CHEMBL75620 1 8.32
CHEMBL461963 1 8.00
CHEMBL6784 1 7.66
CHEMBL20 ACETAZOLAMIDE 4.0 1 7.60
CHEMBL268809 1 7.50
CHEMBL7087 1 7.48
CHEMBL461964 1 7.21
CHEMBL461791 1 7.05
CHEMBL511186 1 6.54
CHEMBL461600 1 6.54
CHEMBL508489 1 6.52
CHEMBL461601 1 5.97
CHEMBL453731 1 5.74
CHEMBL517746 1 5.56

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL366069 Ki = 0.15 nM 9.82
CHEMBL183945 Ki = 0.34 nM 9.47
CHEMBL76956 Ki = 0.8 nM 9.10
CHEMBL75620 Ki = 4.8 nM 8.32
CHEMBL461963 Ki = 10.0 nM 8.00
CHEMBL6784 Ki = 22.0 nM 7.66
CHEMBL20 ACETAZOLAMIDE Ki = 25.0 nM 7.60
CHEMBL268809 Ki = 32.0 nM 7.50
CHEMBL7087 Ki = 33.0 nM 7.48
CHEMBL461964 Ki = 61.6 nM 7.21
CHEMBL461791 Ki = 90.0 nM 7.05
CHEMBL511186 Ki = 290.0 nM 6.54
CHEMBL461600 Ki = 290.0 nM 6.54
CHEMBL508489 Ki = 300.0 nM 6.52
CHEMBL461601 Ki = 1070.0 nM 5.97
CHEMBL453731 Ki = 1840.0 nM 5.74
CHEMBL517746 Ki = 2750.0 nM 5.56