Assay Detail
Binding
CHEMBL1005553
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Inhibition of human recombinant indoleamine 2,3-dioxygenase by Eadie-Hofstee plot
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Structure based development of phenylimidazole-derived inhibitors of indoleamine 2,3-dioxygenase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 5.25 | 5.36 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL14145 | — | — | 1 | 5.36 |
| CHEMBL457610 | — | — | 1 | 5.32 |
| CHEMBL446387 | — | — | 1 | 5.28 |
| CHEMBL457063 | — | — | 1 | 5.05 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL14145 | — | Ki | = | 4400.0 | nM | 5.36 |
| CHEMBL457610 | — | Ki | = | 4800.0 | nM | 5.32 |
| CHEMBL446387 | — | Ki | = | 5300.0 | nM | 5.28 |
| CHEMBL457063 | — | Ki | = | 8900.0 | nM | 5.05 |