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Assay Detail

CHEMBL1005554

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of human recombinant indoleamine 2,3-dioxygenase in presence of D-tryptophan substrate
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Indoleamine 2,3-dioxygenase 1 (CHEMBL4685)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Structure based development of phenylimidazole-derived inhibitors of indoleamine 2,3-dioxygenase.
Kumar S, Jaller D, Patel B, LaLonde JM, DuHadaway JB, Malachowski WP, Prendergast GC, Muller AJ.
J Med Chem (2008) 51 : 4968 -4977
PubMed 18665584 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 1 4.32 4.32

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL14145 1 4.32

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL14145 IC50 = 48000.0 nM 4.32